Rapamycin prolongs female reproductive lifespan
نویسندگان
چکیده
منابع مشابه
Rapamycin prolongs female reproductive lifespan
www.landesbioscience.com Cell Cycle 3353 The pool of ovarian primordial follicles is established during embryonic development in humans, or after birth in rodents, and serves as the source of developing follicles and fertilizable ova for the entire length of female reproductive life. Once the pool of primordial follicles has been exhausted, menopause occurs in women around 50 y old. With modern...
متن کاملFemale post-reproductive lifespan: a general mammalian trait.
Traditional explanations for the evolution of menopause and post-reproductive lifespan in human females have been based on the benefits of maternal or grand-maternal care outweighing the cost of lost reproduction. These explanations assume an evolutionary origin of menopause since human divergence with the most recent common ancestor. In this study, I conduct a literature survey of studies of 4...
متن کاملShort‐term rapamycin treatment increases ovarian lifespan in young and middle‐aged female mice
Although age-related ovarian failure in female mammals cannot be reversed, recent strategies have focused on improving reproductive capacity with age, and rapamycin is one such intervention that has shown a potential for preserving the ovarian follicle pool and preventing premature ovarian failure. However, the application is limited because of its detrimental effects on follicular development ...
متن کاملPharmacological inhibition of NF-κB prolongs lifespan of Drosophila melanogaster
Aging is associated with NF-κB-dependent pro-inflammation. Here we demonstrated that inhibition of NF-κB with pyrrolidine dithiocarbamate increases the median lifespan (13-20%) and the age of 90% mortality (11-14%) in Drosophila melanogaster females and males, respectively.
متن کاملElimination of Unfit Cells Maintains Tissue Health and Prolongs Lifespan
Viable yet damaged cells can accumulate during development and aging. Although eliminating those cells may benefit organ function, identification of this less fit cell population remains challenging. Previously, we identified a molecular mechanism, based on "fitness fingerprints" displayed on cell membranes, which allows direct fitness comparison among cells in Drosophila. Here, we study the ph...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cell Cycle
سال: 2013
ISSN: 1538-4101,1551-4005
DOI: 10.4161/cc.26578